Results
| PMID | 21168580 |
| Gene Name | KRT19 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | Cytokeratin-19 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2011 Jan;95(1):46-9. doi: 10.1016/j.fertnstert.2010.05.016. Epub Tokushige, Natsuko| Markham, Robert| Crossett, Ben| Ahn, Seong B| Nelaturi, Vidya L| Khan, Alamgir| Fraser, Ian S Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, New South Wales, Australia. ntokushige@med.usyd.edu.au OBJECTIVE: To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN: Laboratory study using human urine. SETTING: University-based laboratory. PATIENT(S): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S): Urine collection from women with and without endometriosis. MAIN OUTCOME MEASURE(S): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. RESULT(S): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. CONCLUSION(S): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis. Mesh Terms: Adult| Biomarkers/*urine| Blotting, Western| Endometriosis/*diagnosis/*urine| Female| Humans| Keratin-19/*urine| Proteomics| Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization| Up-Regulation/physiology|DA 2011/01/22 06:00 |
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